| In blood pressure heart rate forearm blood flow venous compliance and cardiac output were discouraging. It was doing a lot less than clinical doses of nitroglycerine said michael allen then clinical project manager and currently director of pfizers early clinical research group. Uk-92,480 was in dire trouble. Viagra acts by inhibiting pde 5... But it still had a pulse thanks primarily to an observation that allen received from one of the preceding safety trials an early 1992 toleration study in the town of merthyr tydfil wales. In that study healthy viagra alternative received three 25-mg doses per day for 10 days. Although the drug was well tolerated at a level of 25 mg the volunteers reported some side effects at higher doses. Allen recalls a telephone conversation with the clinician who was running the trials he mentioned that at 50 mg taken every 8 hours for 10 days there were episodes of indigestion and of aches in patients backs and legs. And he said oh there are also some reports of penile erections. It was not a eureka moment as portrayed in some popular accounts said allen. It was just an observation. Obviously a crucial one. But it was not clear how important the effect was and the participants did not report the erections until they were well into the 10-day trial period. The decision to do the pilot studies in erectile dysfunction patients wasnt that obvious. Erections hadnt been reported until the 4th or 5th day and there were other side effects as well said ian howard osterloh global candidate viagra alternative leader for viagras research and development group. Another factor favored pursuing the finding pfizer scientists thought that they could explain why uk-92,480 caused erections. If they were right. |
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