| Smooth muscle cell relaxation and release of sodium. Elsewhere vascular muscles relax and allow blood vessels to fill with more blood lowering overall blood pressure. Levels of cgmp are held in balance by enzymes known as phosphodiesterases pdes which convert cgmp into gmp by breaking the cgmps cyclic phosphate ring. Gmp is subsequently converted to gtp by another enzyme completing a cycle from gtp to viagra online then gmp and finally back to gtp. It was the viagra online that terrett and his team decided to target for drug develpment reasoning that a pde inhibitor could prevent the breakdown of cgmp created in response to anp. Cgmp concentations would then increase thanks to pde inhibition and if in response smooth muscle cells in the kidney and blood vessels did their part and relaxed blood pressure would drop. And pfizer might have a winner in the hypertension market. To sidebar viagra was discovered... But that reasoning was oversimplified. To succeed the project would have to consider what was being learned about the pdes. Five distinct pde subtypes now up to nine were known then not all of which acted on cgmp. Pde 4 for instance breaks down another secondary messenger cyclic adenosine monosphosphate camp. Clearly inhibiting the wrong pde subtype would kill the project. However inhibiting the right pde subtype without doing so selectively might cause too many side effects. It was also known that different pde subtypes occur in different tissues so terretts team would have to look for a lead compound targeting a pde in the kidney. The team made. |
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